Day 1 :
Hi3 Solutions, USA
Time : 09:40-10:30
Mr. Abdul Malik Shakir is a recognized industry expert in healthcare information management. His information technology experience spans more than four decades, including 35+ years in healthcare. His professional experience includes development of enterprise information architectures, data warehouses / business intelligence applications, systems integration solutions, and expertise in electronic data interchange standards. Mr. Shakir’s consulting experience includes providing advisory services and expert assistance to large-scale healthcare provider organizations and integrated delivery networks. He has contributed to the advancement of healthcare related standards through volunteer participation in Health Level Seven International (HL7), the X12N Healthcare Task Group, the OMG Healthcare Domain Task Force, the Workgroup for Electronic Data Interchange (WEDI), and the IEEE Joint Workgroup for a Common Data Model.
Healthcare information exchange, integration, and analytic capabilities are critical to safe, cost effective, high quality healthcare. The technical infrastructure that serves as an enableler for these capabilities is a complex array of data exchange standards, clinical teminologies, and decision support technologies. This presentation provides an overview of this technical infrastructure and current and emerging technologies. In the area of data exchange standards the presentation will explore the major standards development orgnizations – HL7, X12, IEEE, ASTM, NCPDP, and DICOM; clinical terminologies – ICD, SNOMED, LOINC, RxNORM, and CPT; and technologies – integration engines, terminology servers, standards conformance validators, integrated data repositories, and business intelligence tools. The mission of Hi3 Solutions is to support continuous improvements in healthcare outcomes by providing software solutions and professional services that enable our clients to discover, share, and measure compliance with evidence-based best practices in medicine. The products and services provided by Hi3 Solutions facilitate the use of healthcare information management technology standards designed to enable semantic clinical interoperability.
University of Sao Paulo School of Medicine, Brazil
Keynote: Bioinformatics for Molecular Modeling of human iPS-derived motor neurons reveals pathophysiological mechanisms of Amyotrophic Lateral Sclerosis
Time : 10:30-11:10
Professor Gerson Chadi, MD. PHD., is Full Professor at the Department of Neurology of the University of Sao Paulo Medical School (USP), Brazil, since 1998. He specialized in Neurodegenerative Diseases and Advanced Research on Regeneration of Central Nervous System (CNS) at Karolinska Institute, Sweden (1991-1994), and also at the Clarke Inst of Psychiatry of Univ of Toronto and at the Montreal Neurological Inst of the McGill Univ (1999). He introduced in Brazil the concepts and research methods in the CNS Regeneration (1994) and was one of the signatories of the Beijing Letter which created the Neurorestauratology Discipline in the field of Neurology. He heads the Translational Neurology Unit, the Translational Neurology Laboratory and the Neuroregeneration Research Center at Dep of Neurology of USP. He coordinates the Neurological Genomic Project and the Cell Therapy Project of his Medical School. He introduced the first Brazilian Systematic Translational Research on Amyotrophic Lateral Sclerosis (ALS, bench to bed, side 2010), being responsible for various clinical and laboratory projects on ALS research. He published more than 100 scientific peer reviewed papers in International Scientific Journals, graduated over than 60 Master, PhD and post doctoral students.
The detailed mechanisms related to neurodegeneration in eurodegenerative disorders are still unknown. The methodology to study genetic, molecular and cellular events of human neurological diseases is current under development, increasing the expectation the discovery of therapeutic targets that allow effective translation of proposed clinical trials. Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease that leads to widespread motor neuron death, general palsy and respiratory failure. We have developed the methodology to allow gene expression modeling of sporadic ALS, the most prevalent form of disease, by employing human induced pluripotent stem cell (hiPSC)-differentiated motor neurons linked to DAVID Functional Annotation Bioinformatics Microarray Analysis using a whole human genome platform. DAVID analyses of differentially expressed genes identified molecular function/biological process-related genes through Gene Ontology terms, summarized by REVIGO, and also genes related to KEGG signaling pathways. Specific software for Protein Interaction Network Analysis showed the degree of interaction of deregulated gene expression. The overall analysis showed a strong association between mitochondrial function and cellular processes possibly related to motor neuron degeneration. Supported by: FAPESP and CNPq, Brazil.